Tosylhydrazide-Promoted Diastereoselective Intramolecular 1,3-Dipolar Cycloadditions: Synthesis of Tetrahydropyrrolo[3,4-c]pyrazoles
نویسندگان
چکیده
منابع مشابه
B(C6F5)3-promoted tandem silylation and intramolecular hydrosilylation: diastereoselective synthesis of oxasilinanes and oxasilepanes.
B(C(6)F(5))(3) promotes regio- and stereoselective cyclizations of unsaturated alkoxysilanes to generate oxasilinanes and oxasilepanes. The same products are available directly from alkenols via tandem silylation and hydrosilylation.
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In the present perspective the advances and real possibilities of 1,3-dipolar cycloadditions as key steps in the total synthesis of virus inhibitors are described. Azides, nitrones, and azomethine ylides are the most appropriate 1,3-dipoles for the synthesis of privileged structures with the highest biological responses against viruses.
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Intramolecular formal 1,3-dipolar cycloaddition of ketoimine is developed with PhIO for the first synthesis of fused-Δ(1)-pyrrolines. The scope of the reaction, complete diastereoselectivity and its rationalization by a computational study are reported.
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1,3–Dipolar cycloaddition reactions (DCR) are atom–economic processes that permit the construction of heterocycles. Their enantioselective versions allow for the creation of up to four adjacent chiral centers in a concerted fashion. In particular, well–defined half–sandwich iridium (III) catalysts have been applied to the DCR between enals or methacrylonitrile with nitrones. Excellent yield and...
متن کاملNitrones as dipoles for rapid strain-promoted 1,3-dipolar cycloadditions with cyclooctynes.
Strain-promoted cycloadditions of nitrones with cyclooctynes (k(2) = 1.5 M(-1) s(-1) at 25 degrees C) are up to 25 times more rapid than comparable reactions of azides.
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ژورنال
عنوان ژورنال: European Journal of Organic Chemistry
سال: 2014
ISSN: 1434-193X
DOI: 10.1002/ejoc.201301587